The bulk of endogenously produced IgG2a is eliminated from the serum of adult C57BL/6 mice with a half‐life of 6–8 days

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Abstract
The concentration of IgG2a in the serum of C57BL/6 mice suppressed for the production of IgG2a was measured over a period of 3 months after suppression. The elimination of a minimum of 96% of the endogenous IgG2a molecules from the serum follows an exponential decay with a half-life of 6–8 days. A monoclonal IgG2a antibody injected into suppressed or normal mice is eliminated from the serum in the same fashion. We conclude that there are few, if any, “long-lived” IgG2a molecules present in the serum of C57BL/6 mice under physiological conditions.