Lessons from TGF-β Transgenic Mice
- 23 February 1998
- journal article
- Published by S. Karger AG in Mineral and Electrolyte Metabolism
- Vol. 24 (2-3) , 154-160
- https://doi.org/10.1159/000057364
Abstract
Aberrant expression of TGF-β and/or receptor/signaling function is present in a wide variety of disease processes. Overexpression of TGF-β isoforms in transgenic mice using tissue-specific promoters has provided model systems to study the effects of increased activity of TGF-β in the intact organism. We will review the pertinent features of some of these models, and discuss new insights provided by these studies into regulation and role of TGF-β in health and disease.Keywords
This publication has 6 references indexed in Scilit:
- The recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice.Proceedings of the National Academy of Sciences, 1996
- Tumor suppressor activity of the TGF-β pathway in human cancersCytokine & Growth Factor Reviews, 1996
- TGF-β1 Overexpression in Murine Pancreas Induces Chronic Pancreatitis and Together with TNF-α, Triggers Insulin-Dependent DiabetesBiochemical and Biophysical Research Communications, 1995
- Transforming growth factor‐β: activity and efficacy in animal models of wound healingWound Repair and Regeneration, 1995
- Transforming Growth Factor β in Tissue FibrosisNew England Journal of Medicine, 1994
- Transforming Growth Factor β as a Predictor of Liver and Lung Fibrosis after Autologous Bone Marrow Transplantation for Advanced Breast CancerNew England Journal of Medicine, 1993