NITROGEN DIOXIDE-INDUCED EMPHYSEMA IN RABBITS

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Abstract
Rabbits were continuously exposed to an atmosphere containing 8 to 12 ppm nitrogen dioxide. Destructive changes in the alveolar walls, accompanied by an abnormal enlargement of the distal air spaces, were seen in the lungs of rabbits exposed to nitrogen dioxide for 3 to 4 mo. These changes were not reversible and were compatible with a diagnosis of emphysema. Reversible histopathologic changes in the bronchioles appeared to account for the increase in the nonelastic resistance measured in some of these rabbits.