Pentoxifylline (BL 191) by Oral Administration in the Treatment of Asthenozoospermia

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Abstract
The effect on semen of pentoxifylline administered chronically per os to patients with normogonadotropic asthenozoospermia were studied. Fifteen infertile men (age 22-44 yr) were incorporated. Each subject was submitted to treatment with pentoxifylline per os at a dose of 1200 mg per day during no less than 4 mo. (6.6 .+-. 0.7 mo.). Assessment of the results was performed by serial spermatograms performed during and up to 3 mo. after treatment. The results showed a significant improvement of the percentages of forwardly progressive spermatozoa and of live and motile spermatozoa. Five patients achieved a normalization of semen (frank improvement) and 7 showed a significant improvement in comparison to the initial values. Pregnancy was obtained by 2 patients. Pentoxifylline could be a useful alternative for the treatment of patients with normogonadotropic asthenozoospermia.