A COMPARISON OF EFFECTIVENESS OF 2 FREEZE-DRIED BCG VACCINES AGAINST MYCOBACTERIUM LEPRAE IN MICE

  • 1 January 1968
    • journal article
    • research article
    • Vol. 38  (1) , 135-+
Abstract
BCG vaccination with fresh liquid preparations affords mice protection against M. leprae. The effectiveness of the Japanese and Glaxo freeze-dried BCG vaccines was tested since such preparations would make it possible to administer vaccine of standard viability anywhere in the world, including leprosy-endemic areas. The Japanese and Glaxo vaccines, and the usual fresh liquid preparations, were administered in equivalent amounts to mice, which were then challenged with M. leprae. All the vaccines provided distinct protection although it was not possible to say which vaccine was most effective because their optimal activities were not manifested at comparable times.