Effect of Sequential Infection with Plasmodium vivax and P. falciparum in the Aotus trivirgatus Monkey

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Abstract
A. trivirgatus monkeys with prior experience with P. vivax were inoculated with P. falciparum via the bites of infected mosquitoes [Anopheles freeborini]. The animals with prior malaria had higher parasitemias and significantly higher levels of mosquito infectivity than monkeys with no prior P. vivax experience. Monkeys with a history of P. falciparum inoculated with P. vivax had essentially the same parasitemias as those with no prior malaria. However, levels of mosquito infectivity were markedly increased in those monkeys with a history of P. falciparum. The introduction of another malaria species into a malarious area may result in higher levels of mosquito infection and more rapid establishment and distribution of that species.