APPLICATIONS OF THE MIXED LEUKOCYTE CULTURE TEST TO ESTIMATION OF THE NUMBER OF ALLELES OR LOCI IN THE ???MAJOR??? HISTOCOMPATIBILITY SYSTEMS IN MAN

1 January 1969

journal article
Published by Wolters Kluwer Health in Transplantation

Vol. 7 (1) , 41-48
https://doi.org/10.1097/00007890-196901000-00003

Abstract

SUMMARY It appears that the one-way stimulation mixed leukocyte culture test is able to detect strong histoincompatibilities between two subjects. Each of four types of responses which may be observed on any independent pair of leukocyte mixtures can be predicted with a certain probability depending on the number of alleles and/or loci involved in the “major” histocompatibility system(s). Using simple random sampling of independent leukocyte mixtures, one can estimate the number of alleles or loci. This article is concerned with probability models and experimental designs relevant to this problem.

Keywords

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