Oxidative stress mediates neuronal DNA damage and apoptosis in response to cytosine arabinoside
Open Access
- 15 July 2001
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 78 (2) , 265-275
- https://doi.org/10.1046/j.1471-4159.2001.00395.x
Abstract
Cytosine arabinoside (AraC) is a nucleoside analog that produces significant neurotoxicity in cancer patients. The mechanism by which AraC causes neuronal death is a matter of some debate because the...Keywords
This publication has 53 references indexed in Scilit:
- Differential incorporation of 1‐β‐D‐arabinofuranosylcytosine and 9‐β‐D‐arabinofuranosylguanine into nuclear and mitochondrial DNAFEBS Letters, 2000
- Pharmacokinetics of High-Dose Cytarabine and its Deamination Product-A ReappraisalLeukemia & Lymphoma, 1997
- p53 involves cytosine arabinoside-induced apoptosis in cultured cerebellar granule neuronsNeuroscience Letters, 1996
- A serum-free, pyruvate-free medium that supports neonatal neural/glial culturesJournal of Neuroscience Research, 1995
- The concepts of tail moment and tail inertia in the single cell gel electrophoresis assayMutation Research/DNA Repair, 1995
- Cisplatin Generates Superoxide Anion by Interaction with DNA in a Cell-Free SystemBiochemical and Biophysical Research Communications, 1994
- Vitamin C: The nontoxic, nonrate-limited, antioxidant free radical scavengerMedical Hypotheses, 1985
- Cytosine arabinoside transport and metabolism in acute leukemias and T cell lymphoblastic lymphoma.Journal of Clinical Investigation, 1985
- Cytosine arabinoside transport by human leukaemic cellsEuropean Journal of Cancer and Clinical Oncology, 1983
- DNA Polymerase β from Brain Neurons Is a Repair EnzymeEuropean Journal of Biochemistry, 1979