Autoreactivity against matrilin-1 in a patient with relapsing polychondritis
Open Access
- 2 April 2000
- journal article
- case report
- Published by Wiley in Arthritis & Rheumatism
- Vol. 43 (4) , 939-943
- https://doi.org/10.1002/1529-0131(200004)43:4<939::aid-anr28>3.0.co;2-z
Abstract
Relapsing polychondritis (RP) is a rare inflammatory disease of cartilage. Chondritis of the auricular, nasal, and tracheal cartilages predominates in this disease, suggesting a response to a tissue‐specific antigen. One potential antigen is matrilin‐1, a cartilage matrix protein found uniquely in the tracheal, auricular, and nasal cartilage of adults. We describe herein a patient with RP who had both a humoral and a cellular immune response directed toward the cartilage matrix protein matrilin‐1.Keywords
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