Metagenomic biomarker discovery and explanation
Top Cited Papers
Open Access
- 24 June 2011
- journal article
- research article
- Published by Springer Nature in Genome Biology
- Vol. 12 (6) , R60
- https://doi.org/10.1186/gb-2011-12-6-r60
Abstract
This study describes and validates a new method for metagenomic biomarker discovery by way of class comparison, tests of biological consistency and effect size estimation. This addresses the challenge of finding organisms, genes, or pathways that consistently explain the differences between two or more microbial communities, which is a central problem to the study of metagenomics. We extensively validate our method on several microbiomes and a convenient online interface for the method is provided at http://huttenhower.sph.harvard.edu/lefse/.Keywords
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