Renal Pressor Material in Various Hypertensive Diseases

Publisher Website
Google Scholar
Abstract
Evidence for the presence of a renal pressor substance has been obtained by the use of 2 procedures, one a direct bioassay fo renal venous blood for pressor material, the other an indirect measure of circulating angiotensin, the angiotensin infusion test. Forty-five patients with various hypertensive diseases have been tested. The correlation of the 2 procedures noted in 40 of the 45 patients is taken as evidence for the validity of the infusion test. The results suggest that the following hypertensive states are not related to the activity of a renal pressor mechanism: essential (benign) hypertension, primary aldosteronism, acute glomerulonephritis and chronic renal parenchymal disease. Patients with renal ischemia, from lesions either intrarenal, as in severe accelerated or malignant hypertension, or extrarenal, as in functionally significant renal vascular disease, have an increased activity of the renal pressor system. Further evidence has been presented for the importance of assessing the functional significance of a renal vascular lesion by one or both of these procedures before surgical repair is attempted.

This publication has 2 references indexed in Scilit: