Tryptophan-5-Hydroxylase Maturation in Regions of the Mouse Brain

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Abstract
Trytophan-5-hydroxylase (T5-H) has been measured in four subdivisions of the mouse brain during various stages of postnatal maturation. Patterns of T5-H maturation are very similar to previously measured 5-hydroxytryptamine patterns of maturation. Regional variation is evidenced and most pronounced in the period following the first week after birth. The similarity of maturational pattern for tryptophan-5-hydroxylase and 5-hydroxytryptamine lends support to the idea that the enzyme is a controling factor in the brain’s indoleamine maturation; however, there are reasons to believe that such a conclusion is premature.

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