Pirbenicillin, a New Semisynthetic Penicillin with Broad-Spectrum Activity

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Abstract
Pirbenicillin is a new semisynthetic penicillin which inhibited 67% of isolates of Proteus aeruginosa tested in our laboratory, 93% of P. mirabilis , 31% of Enterobacter spp., 41% of Serratia spp., and 58% of Escherichia coli at a concentration of 6.25 μg/ml. Its activity appeared to be inoculum dependent and it was virtually inactive against 10 7 inocula of P. aeruginosa . It was more active than carbenicillin or ticarcillin, but less active than BL-P1654 against P. aeruginosa . Carbenicillin and ticarcillin appeared to be more active than pirbenicillin against Proteus spp., but pirbenicillin was active against some isolates of Klebsiella spp.