Neisseria meningitidis and Neisseria gonorrhoeae Bacteremia Associated with C6, C7, or C8 Deficiency

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Abstract
Data from 24 previously described or newly diagnosed cases of homozygous deficiency of the 6th, 7th, or 8th components of complement [C] are summarized. Of 24 patients, 13 had at least 1 episode and usually 2 or more episodes of N. meningitidis or N. gonorrhoeae bacteremia or both. Deficiency of C6, C7 or C8 is a meaningful risk factor for repeated neisserial bacteremia; hemolytic C studies are indicated in patient who develop recurrent neisserial infections. When a person with C6, C7 or C8 deficiency is identified, family members should be studied.