In the search for new anticancer drugs. VII
- 1 January 1984
- journal article
- research article
- Published by Springer Nature in Zeitschrift für Krebsforschung und Klinische Onkologie
- Vol. 107 (3) , 217-220
- https://doi.org/10.1007/bf01032610
Abstract
There new diaziridine platinum(II) complexes(4a)-(4c), and a new azetidine platinum(II) complex (3b) were synthesized and tested against the lymphocytic leukemia P388 in mice. Moderate to good activity was found for all compounds as evidenced by a T/C value of 162 at a dose of 32 mg/kg for (3b), 190 at a dose of 32 mg/kg for (4a), 139 at a dose of 4 mg/kg for (4b), and 142 at a dose of 20 mg/kg for (4c).Keywords
This publication has 10 references indexed in Scilit:
- In the Search for New Anticancer Drugs, III+ Phosphorylated Diaziridine DerivativesZeitschrift für Naturforschung B, 1983
- Platinum compounds in cancer chemotherapy.1980
- ANTITUMOR ACTIVITY OF PLATINUM ANALOGSPublished by Elsevier ,1980
- Antileukemia (L1210) activity and toxicity of cis-dichlorodiammineplatinum(II) analogs.1979
- Nephrotoxicity of cis‐platinum (II) dichlorodiammineClinical Pharmacology & Therapeutics, 1978
- AZETIDINEOrganic Syntheses, 1973
- New platinum complexes with anti-tumour activityChemico-Biological Interactions, 1972
- Platinum Compounds: a New Class of Potent Antitumour AgentsNature, 1969
- Cyclische Diazoverbindungen, I. Herstellung und Umsetzungen von DiazirinenEuropean Journal of Inorganic Chemistry, 1961
- Beitrag zur Chemie der Diaza‐cyclopropaneEuropean Journal of Inorganic Chemistry, 1961