Giant appendicular neurofibroma. A light and immunohistochemical study

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Abstract
A case of solitary appendicular neurofibromatosis is presented. The neurogenous nature of the lesion was emphasized by the positive reaction for S‐100 protein. Attention is directed towards the morphological differences between neurogenous hyperplasia, which is a reactive common place feature in the elderly, and the present example of neoplastic nerve growth, which produced a gigantic appendix. A review of the literature failed to disclose any previous case unassociated with von Recklinghausen's disease.