Sensitization to erythrocytes: a distinctive syndrome

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Abstract
In this case of sensitization to erythrocytes, painful purpuric nodules, evanescent neurological complaints and abdominal pain developed in a patient 3 weeks after a traumatic ecchymosis. All hematologic and blood clotting studies were normal. Lesions could be reproduced locally by intradermal injections of either autologous whole red blood cells, autologus red blood cell stroma or purified protein derivative (PPD) of tubercle bacilli, but they could not be reproduced by similar preparations of autologous red blood cell hemolysate, autologus plasma, histamine, calf-thymus DNA, salmon-sperm DNA, phosphatidyl-1-serine or old tuberculin. The patient had an excellent response to cyproheptadine hydrochloride but later was free of lesions after spontaneously stopping treatment,.