C‐6 Glioma Growth in Rats: Suppression with a β‐Adrenergic Agonist and a Phosphodiesterase Inhibitor
- 7 October 1980
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 8 (4) , 447-449
- https://doi.org/10.1002/ana.410080421
Abstract
Rat C‐6 glioma possesses a β‐adrenergic receptor which, when activated, raises intracellular levels of cyclic adenosine monophosphate (cAMP) in cultured C‐6 glioma cells. The present study shows that growth of C‐6 glioma is suppressed in rats treated with the β‐adrenergic agonist isoproterenol. Addition of papaverine, a cAMP phosphodiesterase inhibitor, to the treatment schedule augments this effect. Pharmacological agents that elevate intracellular cAMP levels may retard the growth of neural tumors in vivo.Keywords
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