A novel carbapenem antibiotic, SM-7338 structure-activity relationships.
- 1 January 1990
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 43 (5) , 519-532
- https://doi.org/10.7164/antibiotics.43.519
Abstract
A series of new carbapenem compounds, which have a pyrrolidin-3''-ylthio group substituted with various aminocarbonyl group at C-5'' position as C-2 side chain, have been prepared. The antibacterial activity and the stability to renal dehydropeptidase-I of these compounds were investigated, and the structure-activity relationships were discussed. In this series, SM-7338; (1R,5S,6S)-2-[(3S,5S)-5-dimethylaminocarbonylpyrrolidin-3-ylthio]-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid (5a) was the most interesting compound.This publication has 2 references indexed in Scilit:
- Metabolism of Thienamycin and Related Carbapenem Antibiotics by the Renal Dipeptidase, Dehydropeptidase-IAntimicrobial Agents and Chemotherapy, 1982
- Thienamycin, a new .BETA.-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties.The Journal of Antibiotics, 1979