Is There a Blood-Brain Relationship for Saturated Fatty Acids during Development?
- 1 January 1978
- journal article
- research article
- Published by S. Karger AG in Neonatology
- Vol. 34 (3-4) , 182-186
- https://doi.org/10.1159/000241125
Abstract
Transport of subcutaneously injected [1-14C]-stearic acid through the blood-brain barrier is compared with endogenous biosynthesis (within the brain) during postnatal brain development in mice. The uptake is very important during glial cell multiplication and myelination; endogenous microsomal synthesis is most active during myelination, soluble de novo mechanism is prominent during cell multiplication (mitochondrial systems are not directly related to these events). A parallel is drawn between myelin fatty acids, microsomal synthesis and uptake from the blood.Keywords
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