STUDIES ON PLATELET PLASMA-MEMBRANES .3. MEMBRANE GLYCOPROTEIN LOSS FROM CIRCULATING PLATELETS IN RABBITS - INHIBITION BY ASPIRIN-DIPYRIDAMOLE AND ACCELERATION BY THROMBIN

  • 1 January 1978
    • journal article
    • research article
    • Vol. 91  (2) , 301-306
Abstract
DD125ISA [125I-diazodiiodosulfanilic acid] which binds to platelet surface glycoproteins, is lost more rapidly from double-labeled circulating rabbit platelets than is 51Cr, a label of platelet cytoplasm. Treatment of rabbits with aspirin and dipyridamole to diminish platelet function did not affect 51Cr survival but inhibited DD125ISA loss so that it disappeared from the circulation at the same rate as 51Cr. I.v. thrombin infusion increased DD125ISA loss relative to 51Cr loss. Surface glycoprotein loss was prevented by agents which inhibit platelet function and was accelerated by intravascular coagulation. Platelet surface glycoprotein loss is apparently a continuous process in the normal circulation which may occur during reversible contact interactions in the process of hemostasis and thrombosis.

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