Galanin Inhibits Noradrenaline‐Induced Accumulation of Cyclic AMP in the Rat Cerebral Cortex
- 1 December 1988
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 51 (6) , 1953-1955
- https://doi.org/10.1111/j.1471-4159.1988.tb01185.x
Abstract
The effect of galanin on poradrenaline (NA)-induced accumulation of cyclic AMP was investigated in slices of rat cerebral cortex. NA (10−4M) increased cyclic AMP levels during a 20-min observation period. Galanin (3 × 10−7M) significantly inhibited this response at all time points examined, although it did not change the basal levels of cyclic AMP. Galanin (10−3× 10−6M) inhibited the cyclic AMP response to NA (10−4M) in a dose-dependent manner, with an IC50 of ∼5.6 × 10−5M and a maximum inhibition of 59%. These results suggest that galanin, devoid of any detectable effects by itself, modulates the cyclic AMP response to NA in the rat cerebral cortex.Keywords
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