Carbon-Acylation with Carboxylic-Diphenylphosphinic Anhydrides
- 1 January 1978
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 8 (1) , 59-63
- https://doi.org/10.1080/00397917808062184
Abstract
The reaction of carboxylic acids with chlorodiphenylphosphinite1 in the presence of tertiary amines has been shown to yield moderately stable mixed anhydrides (I) (Equation 1) which are effective N-acylating agents in peptide synthesis. We now report the utility of such anhydrides for carbon acylation leading to ketones and acylmalonic esters.Keywords
This publication has 3 references indexed in Scilit:
- Activation of carboxylic acids as diphenylphosphinic mixed anhydrides: application to peptide chemistryTetrahedron Letters, 1976
- Displacement at phosphorus by a mechanism with A1 character. Acid-catalyzed hydrolysis of phosphinanilidesJournal of the American Chemical Society, 1973
- The Total Synthesis of DaunomycinoneCanadian Journal of Chemistry, 1973