Aplastic Anemia — Suppressor Lymphocytes and Hematopoiesis

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Abstract
The pathogenesis of most cases of aplastic anemia has been enigmatic. To be sure, in some patients direct damage to stem cells by poisons, toxins or drugs can be assumed. But even in circumstances in which a specific toxin or drug can be implicated, the exact pathogenesis of the hematopoietic failure remains obscure. Exciting recent evidence suggests that lymphocytes in the bone marrow or even lymphocytes present in the peripheral blood may play an important part in pathogenesis of aplastic anemia and pancytopenia. An article by Hoffman et al.1 in this issue of the Journal reports studies showing the presence . . .