Nuclear receptor that identifies a novel retinoic acid response pathway
- 1 May 1990
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 345 (6272) , 224-229
- https://doi.org/10.1038/345224a0
Abstract
Molecular cloning and transcriptional activation studies have revealed a new protein similar to the steroid hormone receptors and which responds specifically to vitamin A metabolites. This protein is substantially different in primary structure and ligand specificity from the products of the previously described retinoic acid receptor gene family. By indicating the existence of an additional pathway through which retinoic acid may exert its effects, these data lead to a re-evaluation of retinoid physiology.Keywords
This publication has 46 references indexed in Scilit:
- Retinoids, homeobox genes, and limb morphogenesisNeuron, 1989
- Nuclear receptors enhance our understanding of transcription regulationTrends in Genetics, 1988
- The Steroid and Thyroid Hormone Receptor SuperfamilyScience, 1988
- An early effect of retinoic acid: cloning of an mRNA (Era-1) exhibiting rapid and protein synthesis-independent induction during teratocarcinoma stem cell differentiation.Proceedings of the National Academy of Sciences, 1988
- Identification and spatial distribution of retinoids in the developing chick limb budNature, 1987
- We have a morphogen!Nature, 1987
- The effect of vitamin A on limb regeneration in Rana temporariaDevelopmental Biology, 1983
- Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid.Proceedings of the National Academy of Sciences, 1980
- Stimulation of differentiation of several murine embryonal carcinoma cell lines by retinoic acidExperimental Cell Research, 1979
- The induction of differentiation in teratocarcinoma stem cells by retinoic acidCell, 1978