Eine einfache Synthese von 3‐Methoxypyridin und seinen Analogen durch Alkylierungsreaktionen

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Abstract
A Simple Synthesis of 3‐Methoxypyridine and of Analogues by Alkylation ReactionsSolid potassiumhydroxide in dimethylsulfoxide has high basicity but only low nucleophilicity and is used as a base for the methylation of 3‐hydroxypridine (1) and of analogues with methyliodide. The reaction is not interferred by the addition of small amounts of water and gives yields of 40 percent for the reaction of 1 and up to 100 percent for analogues. The described reagent therefore may be an alternative to lithium diisopropylamide.

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