Cell membrane‐mediated cytolysis by membranes from noncytolytic cells
- 1 January 1978
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 8 (1) , 71-75
- https://doi.org/10.1002/eji.1830080115
Abstract
Cytolysis was obtained with plasma membrane fractions prepared not only from cytolytic T cells, but also from nonimmune lymphoid cells and, moreover, from cell lines of nonlymphoid origin displaying no lytic ability. Furthermore, no relationship exists between the genetic specificity of T cell‐mediated cytolysis and the activity of membrane preparations. If anything, it appears that certain cell types may be unusually sensitive to membrane‐mediated cytolysis. Our observations argue against a mechanistic relationship between T cell‐mediated and membrane‐mediated cytolysis.Keywords
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