Acylfulvenes, a new class of potent antitumor agents
- 1 January 1996
- journal article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 52 (1) , 75-80
- https://doi.org/10.1007/bf01922420
Abstract
Acylfulvene, derived from the sesquiterpene illudin S by treatment with acid (reverse Prins reaction), is far less reactive to thiols than illudin S. However, it is reduced readily to an aromatic product, in the same way as illudin S. This may explain its greatly improved therapeutic index compared to that of the parent compound.Keywords
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