Modular Synthesis of Pantetheine and Phosphopantetheine
- 25 November 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 6 (26) , 4801-4803
- https://doi.org/10.1021/ol048853+
Abstract
D-Pantetheine and d-phosphopantetheine, precursors to coenzyme A, have been synthesized though a linear sequence from three modules (M1−M3) in 9 and 10 steps, respectively. These routes provide access to analogues of coenzyme A containing modified cystamines, β-alanines, and pantoic acid residues. All three modules were joined using conventional methods of peptide synthesis. The chiral component, M3, was derived from d-pantolactone.Keywords
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