GENETICALLY-DETERMINED SUSCEPTIBILITY OF FISCHER 344 RATS TO PROPYLNITROSOUREA-INDUCED THYMIC LYMPHOMAS

  • 1 January 1985
    • journal article
    • research article
    • Vol. 45  (4) , 1483-1487
Abstract
Administration of propylnitrosourea orally induced a high incidence of hematolymphatic neoplasms in all 6 rat strains studied. Remarkable strain differences in susceptibility to thymic lymphomas were observed. The incidence of thymic lymphomas was high in Fischer 344 (98%) and Wistar/Furth (71%) but low in Sprague-Dawley (29%), ACI/Ms (23%), Donryu (24%), and Long-Evans (10%) strains. Segregation of thymic lymphoma incidence among crosses between highly susceptible Fischer and poorly suceptible Long-Evans rats indicated that the increased susceptibility to thymic lymphomas of Fischer rats was determined by a dominant gene Tis-1 (thymic lymphoma susceptible), and that this gene was linked to the coat color loci, p and c, in Linkage Group I in the order of Tis-1-c-p. The presence of another independently assorting dominant gene, Tis-2, was also suggested to accelerate the thymic lymphomagenesis. Expression of the group-specific antigen of murine leukemia virus as well as infectious viruses was not detected in 9 propylnitrosourea-induced thymic lymphomas of Fischer rats.