Durable Clinical and Pathologic Response of Hepatocellular Carcinoma to Systemic and Hepatic Arterial Administration of Platinol, Recombinant Interferon α 2B, Doxorubicin, and 5-Fluorouracil

Abstract
The case described here illustrates the antitumor activity of a four-drug systemic combination chemobiotherapy with platinol, recombinant interferon alpha 2b, doxorubicin (Adriamycin), and 5-fluorouracil (5-FU) (PIAF) in a patient with diffuse hepatocellular carcinoma involving the liver and lungs.