Glucuronidated and sulfated bile acids in serum of patients with acute hepatitis
- 1 May 1986
- journal article
- research article
- Published by Springer Nature in Digestive Diseases and Sciences
- Vol. 31 (5) , 487-491
- https://doi.org/10.1007/bf01320312
Abstract
The concentrations of glucuronidated and sulfated bile acids in the serum of 15 patients with acute hepatitis were determined by mass fragmentography. Total serum bile acid levels were 13.79–444.10 μmol/liter, and the percentages of glucuronidated and sulfated bile acids were in the wide ranges of 1.7–33% and 2.4–49%, respectively. In four of the five patients for whom serum bile acids were analyzed serially from the acute to the recovery stages of acute hepatitis, the decrease of the glucuronidated and sulfated bile acids was slower than that of nonglucuronidated, nonsulfated bile acids. Thus, the relative proportion of the glucuronides and sulfates in total bile acids apparently increased during the recovery phase. The mechanism for the relative predominance of bile acid esters in serum during recovery is unknown but might reflect an improved excretion of the nonesterified bile acids into bile after the rapid recovery of intrahepatic cholestasis.Keywords
This publication has 25 references indexed in Scilit:
- Profiles of bile acids and their glucuronide and sulphate conjugates in the serum, urine and bile from patients undergoing bile drainage.Gut, 1985
- Serum Concentrations of Bile Acid Glucuronides in Hepatobiliary DiseasesDigestion, 1983
- Serum bile acids and alanine aminotransferase concentrations. Comparison of efficacy as indirect means of identifying carriers of non-A, non-B hepatitis agents and of onset, severity, and duration of posttransfusion non-A, non-B hepatitis in recipientsJAMA, 1981
- Analysis of bile acid glucuronides in urine. Identification of 3α,6α,12α-trihydroxy-5β-cholanoic acidThe Journal of Steroid Biochemistry and Molecular Biology, 1980
- Bile acids and their sulphated and glucuronidated derivatives in bile, plasma, and urine of children with intrahepatic cholestasis: effects of phenobarbital treatmentEuropean Journal of Clinical Investigation, 1980
- Postprandial changes in serum concentrations of individual bile salts in normal subjects and patients with acute viral hepatitisDigestive Diseases and Sciences, 1978
- Synthesis of the specific monosulfates of cholic acidSteroids, 1975
- Sensitivity of serum bile acid assay for detection of liver damage in viral hepatitis type B prospective study in five patientsDigestive Diseases and Sciences, 1974
- Quantitative Determination of Conjugated Bile Acids in Serum in Acute HepatitisNature, 1967
- Bile Acid Content of Human Serum. I. Serum Bile Acids in Patients with Hepatic Disease1Journal of Clinical Investigation, 1957