EFFECT OF STREPTOKINASE-STREPTODORNASE ON PERITONEAL TALC ADHESIONS AND GRANULOMAS

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Abstract
STREPTOKINASE-streptodornase mixtures (Sk-Sd) have been used in a variety of clinical conditions characterized by the presence of purulent exudates or coagulated blood. The results obtained by local application or by instillation have been favorable in thoracic empyema, hemothorax and pleural effusions,* gangrene of the extremities,9infected sinus tracts,† osteomyelitis,9tuberculous meningitis and adenitis,‡ burns,16and miscellaneous soft tissue infections.§ The data suggest that streptokinase-streptodornase mixtures exert a double action. The streptokinase, in the presence of a serum component, lyses fibrin.∥ The streptodornase depolymerizes desoxyribonucleoprotein which accumulates in purulent exudates from the nuclei of dead cells.¶ The final result is a liquefaction of purulent or clotted material which is readily removed. The present experiments were initiated to study the effects of Sk-Sd on peritoneal adhesions. It was assumed that these enzymes liquefy fibrinous and nucleoprotein exudates and, thus, that they might prevent peritoneal adhesions which develop from such

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