EXPERIMENTAL APPROACH TO FIBROUS HISTIOCYTOMA

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Abstract
A transplantable tumor was produced in syngeneic mice inoculated with transformed bone marrow macrophages (28-12 and L-18 cell lines). The tumor composed of proliferative spindle cells was arranged in a storiform pattern and was similar to that of human fibrous histiocytoma. By EM, the tumorous spindle cells had fibroblastic characteristics. Functionally, the tumor cells had histiocytic characteristics and consisted of a transitional form between histiocytes and fibroblasts. The spindle cells may be facultative fibroblasts. This finding is compatible with the hypothesis that fibrous histiocytoma is derived from histiocytes.