Changes in Adrenals and Other Organs Following Exposure of Hairless Mice to Intense Sound

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Abstract
Systemic effects in hairless mice were studied following local abdominal and scrotal skin exposure to intense air-borne sound. Comparisons were made between effects of moderately high (150 db, 18 kc) and high (160-168 db, 20 kc) levels of sound. Examination of control mice revealed that 10-minute daily immobilization for 1 to 3 months was sufficiently stressful to cause an hypertrophy of the adrenal cortex and involution of the thymus. Evidence was also obtained which indicated that there was an increased adrenal response in immobilized mice which were exposed to moderately high levels of sound for periods of one to three months. It was concluded from these studies that immobilization and sound vibrations on the skin surface can both be considered stressful. The absence of gonadal damage and slight changes in the hemopoietic system indicated these are mild rather than severe stress stimuli. In other experiments where more intense sound was used, the local and systemic response was similar to that known to occur following ordinary skin burns. In these cases heat and not sound was the stressor agent involved.

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