EFFECT OF SEROTONIN UPTAKE BLOCKING-AGENTS ON FLEXOR REFLEX OF HIND LIMB OF SPINAL RAT

  • 1 January 1977
    • journal article
    • research article
    • Vol. 29  (4) , 367-376
Abstract
Imipramine, clomipramine, FG 4963 [+-trans-3,4-methoxyphenoxymethyl-1-methyl-4-phenyl-piperidine hydrochloride] and quipazine potentiated the flexor reflex of the hindlimb of the spinal rat, imipramine and clomipramine being relatively weak, and quipazine the most potent in this respect. The potentiation was prevented by serotonin receptor blocking agents, cyproheptadine and danitracen. Imipramine and clomipramine prevented the potentiation of flexor reflex by fenfluramine; this indicated a presynaptic mechanism of action of the latter compound. The stimulatory action of LSD was only partially inhibited by imipramine. The action of quipazine seemed mainly postsynaptic, as it was not prevented by severe depletion of serotonin stores by reserpine and an inhibitor of serotonin synthesis, H 25/54 [.alpha.-propyldopacetamide].