Synthesis and Coordination Chemistry of the First Water-Soluble Dithio−Bis(phosphine) Ligands [(HOH2C)2P(CH2)2S−X−S(CH2)2P(CH2OH)2] (X = (CH2)3 or C6H4). X-ray Crystal Structure of [Pd(HOH2C)2P(CH2)2S(CH2)3S(CH2)2P(CH2OH)2](Cl)21

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Abstract
The thioether-functionalized, water-soluble, bis(phosphines) (HOH(2)C)(2)PCH(2)CH(2)S(CH(2))(3)SCH(2)CH(2)P(CH(2)OH)(2) (9) and C(6)H(4){1,2-SCH(2)CH(2)P(CH(2)OH)(2)}(2) (10) were synthesized in near quantitative yields by the formylation of the appropriate phosphine hydrides in the presence of formaldehyde in ethanol. The reactions of 9 and 10 with Pt(COD)Cl(2) and Pd(C(6)H(5)CN)(2)Cl(2) in biphasic media (aqueous/organic) produced the water-soluble Pt(II) and Pd(II) complexes [Pt(HOH(2)C)(2)P(CH(2))(2)S(CH(2))(3)S(CH(2))(2)P(CH(2)OH)(2)](Cl)(2) (11), [Pd(HOH(2)C)(2)P(CH(2))(2)S(CH(2))(3)S(CH(2))(2)P(CH(2)OH)(2)](Cl)(2) (12), [Pt{(C(6)H(4)){1,2-S(CH(2))(2)P(CH(2)OH)(2)}(2)}](Cl)(2) (13), and [Pd{(C(6)H(4)){1,2-S(CH(2))(2)P(CH(2)OH)(2)}(2)}](Cl)(2) (14) in near quantitative yields. The X-ray crystal structure of 12 confirms a square-planar Pd(II) structure for this new generation of water-soluble transition metal complexes. All of the complexes were characterized by MS, (1)H, (13)C, and (31)P NMR spectroscopy. X-ray data for 12: triclinic, P&onemacr;, a = 9.9761(6) Å, b = 10.2049(7) Å, c = 11.6954(7) Å, alpha = 67.730(10) degrees, beta = 69.943(10) degrees, gamma = 79.828(10) degrees, Z = 2, R = 0.0307 (R(w) = 0.0797).

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