EFFECT OF HYPER-TRANSFUSION ON BONE-MARROW REGENERATION IN SUBLETHALLY IRRADIATED MICE .1. ENHANCED GRANULOPOIETIC RECOVERY

  • 1 January 1980
    • journal article
    • research article
    • Vol. 56  (1) , 52-57
Abstract
Hypertransfusion can enhance recovery from neutropenia in certain clinical situations. The pattern of myeloid recovery in mice hypertransfused after receiving 350 rads whole body irradiation was studied. The hypertransfused and control groups showed the degenerative phase, abortive rise and regenerative phase described following sublethal irradiation. The blood granulocyte counts in the hypertransfused group returned to normal more rapidly and were maintained at a signicantly higher level during the regenerative phase. This difference was not the result of a shift in granulocytes from the marrow granulocyte reserve or marginal granulocyte pool to the circulating pool, but was associated with significantly enhanced bone marrow granulopoiesis. Although the total bone marrow cellularity of the hypertransfused mice was less than the control mice, the hypertransfused group contained more CFU-GM [granulocyte macrophage colony forming unit] and myeloid cells during the regenerative phase. The enhanced granulopoiesis was not due to increased colony-stimulating activity (CSA) levels in the hypertransfused mice, as the CSA levels were significantly lower in this group compared to the controls prior to and during the initial phase of granulopoietic recovery. Hypertransfusion apparently increases the rate of recovery of myelopoiesis by increasing the number of precursors available for myeloid differentiation from an earlier stem cell compartment.