In spite of the detailed comparative anatomic studies of Minkowski,1 Brouwer and Zeeman,2 Poliak 3 and others,4 the macular projection on the cerebral cortex is still a subject of controversy. Lack of satisfactory methods for mapping the central visual fields of animals leaves the functional significance of such anatomic studies in question. On the other hand, there have been few reports thus far of histologic studies of the lesion in human beings combined with controlled investigation of the visual functions. Neurosurgical advances in recent years have made possible the investigation of patients with circumscribed cerebral lesions under the controlled conditions of the experimental laboratory. During the past three years, we have been privileged to study 2 cases presenting unusual opportunities for a detailed investigation of the cortical projection of the macula.