Hypoxic pulmonary hypertension of the calf with denervation of the lungs

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Abstract
Transection of the spinal cord at the level of C2, spinal anesthesia, and/or bilateral vagotomy were done in 11 healthy young male calves. These procedures did not block the pulmonary arterial pressure rise with 12 or 9% oxygen, but they did block the increase in heart rate and systemic arterial pressure which accompanied hypoxia when the central nervous system was intact. The central nervous system, therefore, appeared to mediate the response to acute hypoxia of the systemic circulation, but not the pulmonary arterial pressure rise. hypoxia; pulmonary circulation; spinal cord section; spinal anesthesia; vagotomy Submitted on February 19, 1964

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