Correlation between the Dose and Development of Acute Tolerance to the Hypothermic Effect of THC
- 1 January 1980
- journal article
- research article
- Published by S. Karger AG in Pharmacology
- Vol. 21 (6) , 391-395
- https://doi.org/10.1159/000137458
Abstract
The administration of 0.3–40 mg/kg Δ9-tetrahydrocannabinol (THC) produced a dose-dependent hypothermia in rats. The maximal hypothermic effect was obtained with the dose of 2.5 mg/kg of THC. When the same doses of THC were repeated on days 2 and 3, tolerance to the hypothermic effect of THC was apparent. Doses of THC higher than 2.5 mg/kg induced a significant and dose-dependent tolerance after the first administration whereas with the lower doses, tolerance was only apparent after the second injection. The possible mechanism of these effects of THC is discussed.Keywords
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