Serum C′3 Lytic System in Patients with Glomerulonephritis
- 25 April 1969
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 164 (3878) , 436-437
- https://doi.org/10.1126/science.164.3878.436
Abstract
The serums of patients with hypocomplementemic glomerulonephritis contain a substance that combines with a normal serum cofactor in the presence of magnesium ion to specifically cleave the third component of complement. This lysis of C′3 is 80 to 90 percent complete in 20 minutes at 37°C and p H 7. Neither the nephritic factor nor its cofactor is identifiable with the complement system.Keywords
This publication has 7 references indexed in Scilit:
- A “silent” phase of hypocomplementemic persistent nephritis detectable by reduced serum β1C-globulin levelsThe Journal of Pediatrics, 1969
- Three Naturally-Occurring Inhibitors of Components of Complement in Guinea Pig and Rabbit SerumThe Journal of Immunology, 1967
- FORMATION AND FUNCTIONAL SIGNIFICANCE OF A MOLECULAR COMPLEX DERIVED FROM THE SECOND AND THE FOURTH COMPONENT OF HUMAN COMPLEMENTThe Journal of Experimental Medicine, 1967
- Complement Activity and Inflammatory Neutrophil Exudation in ManInternational Archives of Allergy and Immunology, 1967
- Antigenic Determinants of Human β1C- and β1G-GlobulinsThe Journal of Immunology, 1966
- Hypocomplementemic and normocomplementemic persistent (chronic) glomerulonephritis; clinical and pathologic characteristicsThe Journal of Pediatrics, 1965
- ISOLATION AND DESCRIPTION OF THE FOURTH COMPONENT OF HUMAN COMPLEMENTThe Journal of Experimental Medicine, 1963