Successful adjuvant-free vaccination of BALB/c mice with mutated amyloid β peptides
Open Access
- 18 February 2008
- journal article
- Published by Springer Nature in BMC Neuroscience
- Vol. 9 (1) , 25
- https://doi.org/10.1186/1471-2202-9-25
Abstract
A recent human clinical trial of an Alzheimer's disease (AD) vaccine using amyloid beta (Aβ) 1–42 plus QS-21 adjuvant produced some positive results, but was halted due to meningoencephalitis in some participants. The development of a vaccine with mutant Aβ peptides that avoids the use of an adjuvant may result in an effective and safer human vaccine.Keywords
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