CHANGES IN THE HOST RESPONSE FOLLOWING TREATMENT WITH LYOPHILIZED TISSUE

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Abstract
BALB/c [mouse] hosts were immunized i.v. with lyophilized preparations of the C3H ascites tumour, B.P.8, and later challenged with viable suspensions of the same tumour. The rate of graft destruction in such animals varied according to the interval between pretreatment and challenge. Grafts transplanted 8 days after pretreatment were destroyed at an accelerated rate. Those transplanted 16[long dash]19 days after pretreatment showed enhanced survival. Transplants made between these times showed intermediate survival times. The rate at which this phasic change in host reactivity occurred depended on antigen dose. Other BALB/c hosts similarly immunized with lyophilized tissue developed peak haemagglutinin titres just prior to the phase at which graft enhancement could be demonstrated. It is pointed out that immuno-logical enhancement cannot be fully explained by a failure of the host to develop an immune response. It is suggested that cellular reactivity akin to delayed hypersensitivity is suppressed by excess antibody and that this is the normal homeostatic mechanism controlling the duration of delayed hypersensitivity.

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