Effect of Intravenous Histamine, Allergen (Ascaris suum Extract) and Compound 48/80 and Inhaled Allergen-Aerosol on Bronchoconstriction and Histamine Release

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Abstract
The effect of a histamine releaser (compound 48/80), an antigen (A. suum extract) and of exogenous histamine infusion on antigen aerosol-induced bronchoconstriction was investigated in 24 mongrel dogs. During these substance infusions the high values of arterial plasma histamine did not correlate with the degree of bronchoconstriction. Severe bronchoconstriction with a relatively low arterial plasma histamine concentration was observed during antigen inhalation. During substance inhalation a high local concentration of histamine may explain the increased bronchial sensitivity to actual plasma levels of histamine. Responsiveness of the bronchial tree to antigen aerosol was reduced 90 min after induction of a strong histamine release. The importance of histamine in the 1st phase of immediate hypersensitivity is discussed.