Humoral Factor in Irradiation Protection: Modification of Lethal Irradiation Injury in Mice by Injection of Rat Bone Marrow

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Abstract
Data presented give further evidence for a humoral factor in postirradiation protection by injn. of bone marrow suspensions. Total body exposures of 800 r and 900 r are 100% lethal to LAF1 and Strain A mice. Bone marrow from Osborne-Mendel rats given intraven. to irradiated LAF1 mice resulted in .0-30% mortality at 21 days and in irradiated Strain A mice, 45% mortality at 21 days. Bone marrow from Sprague-Dawley rats given intraven. to irradiated LAF1 mice gave 30-80% mortality at 21 days and intraperit., 100% mortality. Sprague-Dawley rat bone marrow given intraven. to irradiated Strain A mice gave an 85% mortality at 21 days. Bone marrow from Fischer rats given intraven. did not alter the 100% mortality of irradiated Strain A mice. The same type of bone marrow given intraperit. to irradiated LAF1 mice resulted in 86% mortality at 21 days.