13C‐Markierung der Seitenketten von Mitoxantrone
- 1 January 1989
- journal article
- Published by Wiley in Journal of Labelled Compounds and Radiopharmaceuticals
- Vol. 27 (1) , 91-101
- https://doi.org/10.1002/jlcr.2580270113
Abstract
5,8‐Bis‐{[1‐13C]‐{[2‐[(2‐hydroxyethyl)amino]ethyl]amino}}‐1,4‐dihydroxy‐9,10‐anthracenedione dihydrochloride is synthesized in 28% yield from [13C]‐sodium cyanide via a five step sequence. The described synthesis of the sidechain, 2‐[(2‐aminoethyl)amino]ethanol, allows the labelling of each position of the carbon skeleton by taking use of only one intermediate, which is easy to prepare in very good yield.Keywords
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