Anaemia in mice caused by Eperythrozoon coccoides (Schilling, 1928)

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Abstract
Experiments were designed to dissociate the effect of Eperyfhrozoon coccoides on the blood of mice from the effect of splenectomy. Both agents caused a decrease in number of red blood cells which was followed by an increased production of reticulocytes. The anaemic condition caused by the eperythrozoa persisted for more than 230 days after splenectomy, and parasites were seen in fluctuating numbers at intervals throughout this period.At the height of infection, red blood cells were more fragile than normal in hypotonic saline and the blood clotted more rapidly than normal. No breakdown products of haemoglobin were detected in the urine or serum, and no haemolysins or haemagglutinins were detected in the serum. The white cell count was usually increased after heavy infections, the chief increase being in the number of myelocytes and other immature cells.

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