BCG VACCINATION IN TUBERCULOUS HOUSEHOLDS

Publisher Website
Google Scholar
Abstract
A nineteen-year (1941-1960) strictly controlled BCG vaccination study in newborn infants from tuberculous households, all isolated after birth in foster homes, is presented. The home and environmental contact with tuberculosis of the control and vaccinated groups was analyzed and assessed statistically and was found to be similar. Other factors, such as sex, race, birth weight, follow-up care, and subsequent diseases, were likewise found to be similar in both groups and were verified statistically. In the 231 vaccinated persons there was a total of 3 cases of tuberculosis (0.68 per 1000 per year), and in the 220 not vaccinated (placebo) there were 11 cases of tuberculosis (2.62 per 1000 per year), a reduction of 74% in favor of the vaccinated. This difference is statistically significant (P= 0.043). There were 7 cases of nonfatal disease among the controls (1.67 per 1000 per year) and 3 among the vaccinated (0.68 per 1000 per year). There were 4 deaths from tuberculosis among the controls (0.96 per 1000 per year) and none among the vaccinated. There were no cases of tuberculous meningitis or miliary tuberculosis in the vaccinated, whereas there were 4 such cases in the controls. The multiple-puncture method of vaccination was employed. There was a 99.6% tuberculin conversion rate.

This publication has 0 references indexed in Scilit: