RELATIVE INVITRO STABILITY OF ORNITHINE DECARBOXYLASE FROM LIVER PRENEOPLASTIC NODULES AND HEPATOMAS

  • 1 January 1983
    • journal article
    • research article
    • Vol. 43  (5) , 2298-2300
Abstract
A very rapid and drastic microsome-dependent in vitro inactivation of the hydrocortisone-induced ornithine decarboxylase in rat liver was reported recently (M. F. Zuretti and E. Gravela, 1983). Ornithine decarboxylase from preneoplastic nodules and hepatomas, induced in rats by N-2-fluorenylacetamide, is much more stable, its greater stability not being accounted for by a lower microsome-bound inactivating capacity. The possibility of a relationship between the in vitro enzyme stability and the increase of enzyme activity in neoplastic tissues is suggested.

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